You need to know what you are running across before you commit. 16" of water over a soft mud bottom is very different than 16" of water over gravel or rocks.
Does your rig have a jackplate, or fixed-mounted engine? You should be able to figure how your boat runs, do some measurements and have a good idea of how much water you need. You probably have already done this.
If you can run in 15" of water, theoretically you could run in 16", but a single 2" hump or rock or log could be bad, again depending on the bottom.
Do you have an aluminum or stainless prop? I'd be more concerned about your skeg and lower unit than the prop. Props are easy to fix, but significant damage to a stainless prop usually means more damage to the lower unit.
I have a tunnel hull boat that I built for fishing flats in FL, a shallow water machine. We ran over sand bottoms though, no rocks in sight.
Shallow water is a good argument for "when in doubt, don't."